REAL TIME FLUORESCENCE IMAGING OF SIRT1 CYTOSOLIC TRANSLOCATION UNDER THE TREATM

Sirtuins comprise a family of enzymes implicated in the determination of organismal lifespan in yeast and the nematode. Human sirtuin SIRT1 has been shown to deacetylate several proteins in a NADt-dependent manner. It is reported that SIRT1 regulates physiological processes including senescence, fat