From identification of fluorescent flavoproteins to mitochondrial redox indicato

Development of the use of flavin and nicotinamide-adenine nucleotide fluorescence in monitoring the redox state of the free mitochondrial NADH/NADt couple in cells, tissues and organs is reviewed. A break-through was the identification of dihydrolipoamide dehydrogenase (FpL) as the major NAD-linked